![]() ![]() Our findings will provide researchers with a new understanding of co-methylation patterns in breast cancer. Finally, the network analyses of genes associated with several sets of co-methylated CG sites identified above show that tumor and normal samples have different patterns. Sixth, chromosome X co-methylation patterns are very different from other chromosomes. Fifth, both highly changing sites and super-connector sites’ locations are significantly different from the genome-wide CG sites’ locations. The top 100 of such super-connector CG sites in tumor and normal samples have no overlaps. ![]() Fourth, certain CG sites are highly correlated with many CG sites. The percentage of differentially methylated (DM) sites among them is larger than the overall DM rate. Third, a small proportion of CG sites’ co-methylation patterns change dramatically from normal to tumor. Highly co-methylated pairs on the same chromosome tend to be close to each other. Second, both tumor and normal samples have about 94% of co-methylated CG pairs on different chromosomes, but normal samples have 470 million more CG pairs. Both tumor and normal samples have more than 93% positive co-methylation, but normal samples have significantly more negatively correlated CG sites than tumor samples (6.6% vs. First, normal samples have more highly correlated, or co-methylated, CG pairs than tumor samples. In this study, we analyze much larger datasets (Illumina 450K data). Previous studies are conducted using relatively small datasets (Illumina 27K data). It is still not clear how different genes co-methylate in the whole genome of breast cancer samples. ![]() This correlation pattern is known as co-methylation. The methylation levels of different genes in a genome are correlated in certain ways that affect gene functions. It is associated with DNA methylation, an epigenetic event with a methyl group added to a cytosine paired with a guanine, i.e., a CG site. Breast cancer is one of the most commonly diagnosed cancers. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |